※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

  Reviewed (2)  or Unreviewed (15) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-POA-00015	ENSPPYG00000008219	DUSP14
2		EPS-POA-00013	ENSPPYG00000008353	DUSP3
3		EPS-POA-00017	ENSPPYG00000010895	DUSP15
4		EPS-POA-00022	ENSPPYG00000012291	DUSP11
5		EPS-POA-00025	ENSPPYG00000016834	RNGTT
6		EPS-POA-00012	ENSPPYG00000002316	DUSP13
7		EPS-POA-00009	ENSPPYG00000002317	DUPD1
8		EPS-POA-00016	ENSPPYG00000016160	DUSP22
9		EPS-POA-00010	ENSPPYG00000018499	DUSP26
10		EPS-POA-00014	ENSPPYG00000020269	DUSP21
11		EPS-POA-00021	ENSPPYG00000000553	DUSP27
12		EPS-POA-00018	ENSPPYG00000000590	DUSP12
13		EPS-POA-00019	ENSPPYG00000012997	DUSP19
14		EPS-POA-00024	ENSPPYG00000000654	DUSP23
15		EPS-POA-00020	ENSPPYG00000017071	EPM2A
16		EPS-POA-00011	ENSPPYG00000011719	DUSP18
17		EPS-POA-00023	ENSPPYG00000003301	PTPMT1