Danio rerio Other TLK※ TLK family introduction TLK (Tousled-like kinase) are classified into "Other" group (1). TLKs are originally found to encode a ser/thr kinase that is essential for proper flower development in Arabidopsis thaliana. Two homologues have been found in human genome, known as TLK1 and TLK2. Two TLKs share 84% similarity with each other and almost 50% with Arabidopsis TLK. All three TKLs contain nuclear localization signals and predicted coiled-coil regions in N-terminal. The mammalian TLKs share some similar function properties with plant TLK, including a broad expression and preference to similar substrates. In addition, human TLKs play important roles in regulation of cell cycle and reach the maximal activities in S phase (2).
Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Sillje, H.H., Takahashi, K., Tanaka, K., Van Houwe, G. and Nigg, E.A. (1999) Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication . EMBO J, 18, 5691-5702. PMID: 10523312
There are 3 genes. Reviewed (1)
or Unreviewed (2) 
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Sillje, H.H., Takahashi, K., Tanaka, K., Van Houwe, G. and Nigg, E.A. (1999) Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication . EMBO J, 18, 5691-5702. PMID: 10523312
There are 3 genes. Reviewed (1)
or Unreviewed (2) | No. | Status | EKPD ID | Gene ID | Gene Name |
|---|---|---|---|---|
| 1 | | |||
| 2 | | |||
| 3 | |