※ Eph family introduction

    Eph receptor tyrosine kinases are known able to bind their ephrin ligands and act as key regulator of cell contact-dependent signaling and patterning. Eph kinase contains fourteen members which can further be classified into two subclasses A and B in human. EphA1-8 and Eph10 belong to subclass A, EphB1-4 and EphB6 belong to subclass B. Eph kinases consist of two regions: intracellular region and extracellular region. The extracellular part contains a globular ligand-binding domain, a cysteine-rich region and two fibronectin type III repeats. The intracellular part contains a short juxtamembrane region, a kinase catalytic domain, a sterile α motif (SAM) protein−protein interaction domain and a PDZ-binding motif. Eph/ephrin binding will lead to very diverse biological readouts including adhesion versus repulsion and increased versus decreased motility. Depending on the different cell type and context, the interaction will lead to different downstream signaling pathway. In addition, evidence shows that endocytosis of Eph/ephrin and associated tissue-specific effectors are essential for diverse biological roles and processes (1).

Reference
1. Pitulescu, M.E. and Adams, R.H. (2010) Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev, 24, 2480-2492. PMID: 21078817

  Reviewed (0)  or Unreviewed (21) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GAA-00018	ENSGACG00000002696	EPHA10
2		EKS-GAA-00002	ENSGACG00000006268	EPHA7
3		EKS-GAA-00017	ENSGACG00000006527	EPHB1 (2 of 2)
4		EKS-GAA-00003	ENSGACG00000006747	EPHA3
5		EKS-GAA-00009	ENSGACG00000006770	EPHA6 (1 of 2)
6		EKS-GAA-00020	ENSGACG00000015381	EPHA4 (2 of 2)
7		EKS-GAA-00014	ENSGACG00000015384	EPHA6 (2 of 2)
8		EKS-GAA-00008	ENSGACG00000015386
9		EKS-GAA-00013	ENSGACG00000010989	EPHA8
10		EKS-GAA-00019	ENSGACG00000010474	EPHB6
11		EKS-GAA-00016	ENSGACG00000012225	EPHA2 (2 of 2)
12		EKS-GAA-00006	ENSGACG00000012702	EPHB2 (2 of 2)
13		EKS-GAA-00011	ENSGACG00000020695	EPHB4 (1 of 2)
14		EKS-GAA-00005	ENSGACG00000009051	EPHB3 (1 of 2)
15		EKS-GAA-00004	ENSGACG00000004496	EPHB2 (1 of 2)
16		EKS-GAA-00021	ENSGACG00000016078	EPHB3 (2 of 2)
17		EKS-GAA-00001	ENSGACG00000000101	EPHA4 (1 of 2)
18		EKS-GAA-00007	ENSGACG00000013951	EPHB1 (1 of 2)
19		EKS-GAA-00012	ENSGACG00000001154	EPHB4 (2 of 2)
20		EKS-GAA-00010	ENSGACG00000017807	EPHA5
21		EKS-GAA-00015	ENSGACG00000005322	EPHA2 (1 of 2)