※ Eph family introduction

    Eph receptor tyrosine kinases are known able to bind their ephrin ligands and act as key regulator of cell contact-dependent signaling and patterning. Eph kinase contains fourteen members which can further be classified into two subclasses A and B in human. EphA1-8 and Eph10 belong to subclass A, EphB1-4 and EphB6 belong to subclass B. Eph kinases consist of two regions: intracellular region and extracellular region. The extracellular part contains a globular ligand-binding domain, a cysteine-rich region and two fibronectin type III repeats. The intracellular part contains a short juxtamembrane region, a kinase catalytic domain, a sterile α motif (SAM) protein−protein interaction domain and a PDZ-binding motif. Eph/ephrin binding will lead to very diverse biological readouts including adhesion versus repulsion and increased versus decreased motility. Depending on the different cell type and context, the interaction will lead to different downstream signaling pathway. In addition, evidence shows that endocytosis of Eph/ephrin and associated tissue-specific effectors are essential for diverse biological roles and processes (1).

Reference
1. Pitulescu, M.E. and Adams, R.H. (2010) Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev, 24, 2480-2492. PMID: 21078817

  Reviewed (0)  or Unreviewed (13) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-LOA-00011	ENSLAFG00000011971	EPHA8
2		EKS-LOA-00009	ENSLAFG00000022144	EPHB4
3		EKS-LOA-00001	ENSLAFG00000011048	EPHA4
4		EKS-LOA-00010	ENSLAFG00000007699	EPHA2
5		EKS-LOA-00013	ENSLAFG00000017534	EPHA10
6		EKS-LOA-00008	ENSLAFG00000017581	EPHA6
7		EKS-LOA-00002	ENSLAFG00000000048	EPHA3
8		EKS-LOA-00005	ENSLAFG00000006334	EPHB2
9		EKS-LOA-00012	ENSLAFG00000026194	EPHA1
10		EKS-LOA-00004	ENSLAFG00000018084	EPHA7
11		EKS-LOA-00006	ENSLAFG00000013195	EPHB1
12		EKS-LOA-00003	ENSLAFG00000010504	EPHA5
13		EKS-LOA-00007	ENSLAFG00000028654	EPHB3