※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

  Reviewed (0)  or Unreviewed (14) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GAA-00468	ENSGACG00000002001	MAP3K7 (2 of 2)
2		EKS-GAA-00466	ENSGACG00000006251	MAP3K7; MAP3K7 (1 of 2)
3		EKS-GAA-00463	ENSGACG00000006196	MAP3K13
4		EKS-GAA-00465	ENSGACG00000006732	MAP3K12 (1 of 2)
5		EKS-GAA-00464	ENSGACG00000003194	MAP3K12 (2 of 2)
6		EKS-GAA-00471	ENSGACG00000011346	ILK (1 of 2)
7		EKS-GAA-00470	ENSGACG00000015407
8		EKS-GAA-00459	ENSGACG00000010392
9		EKS-GAA-00469	ENSGACG00000012036	FPGT-TNNI3K
10		EKS-GAA-00462	ENSGACG00000012122	MAP3K9
11		EKS-GAA-00460	ENSGACG00000020033	MAP3K11
12		EKS-GAA-00472	ENSGACG00000020592	ILK (2 of 2)
13		EKS-GAA-00467	ENSGACG00000004790
14		EKS-GAA-00461	ENSGACG00000009773	MAP3K10