※ DMPK family introduction

    DMPK (myotonic dystrophy protein kinase) belong to AGC family, which was first described in 1909 to have relation with myotonic dystrophy. The phylogenetic tree of DMPK family shows this family also includes ROCKs (Rho kinases), MRCK (cell division control protein 42 (Cdc42)-binding kinases) and citron kinase. Sequence analysis shows that these kinases contain an amino-terminal kinase catalytic domain followed by a coiled-coil-forming region and other functional motifs at the C-terminus. DMPK have been probed by synthetic peptides or putative physiological substrates to possess Serine/Threonine kinase activity, many proteins targeted by DMPK show a consensus motif R x x S/T L/V R, which is similar to PKC. DMPK have been shown to act as a key molecule in regulation these in varieties of cellular processes, including regulation of skeletal muscle proper structure and function, ion-channel gating control and cell metabolism. In addition, abnormal expression or genetic defect of DMPK associated with myotonic dystrophy 1 (1).

Reference
1. Kaliman, P. and Llagostera, E. (2008) Myotonic dystrophy protein kinase (DMPK) and its role in the pathogenesis of myotonic dystrophy 1. Cell Signal, 20, 1935-1941. PMID: 18583094

  Reviewed (0)  or Unreviewed (6) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SUS-00392	ENSSSCG00000008629	ROCK2
2		EKS-SUS-00391	ENSSSCG00000010862	CDC42BPA; LOC100739027
3		EKS-SUS-00393	ENSSSCG00000009837	CIT
4		EKS-SUS-00390	ENSSSCG00000021893	ROCK1
5		EKS-SUS-00389	ENSSSCG00000013018	CDC42BPG
6		EKS-SUS-00388	ENSSSCG00000002523	CDC42BPB