※ MAST family introduction

    MASTs (Microtubule-associated Serine/Threonine-protein kinases) belong to AGC family. The MAST kinases are characterized by the presence of a Serine/Threonine kinase domain, a second 3' MAST domain and PDZ domain. The PDZ domain has been reported to mediate interaction with others proteins and help MAST facilitate functionally important phosphorylation. The N-terminal kinase catalytic domain is relatively conserved in MAST family, with a high degree identity (>60%). MAST family is expressed in multiple tissues. In nervous system, MAST may act as a key role through localization within the DAPC/UAPC, which is found within region of the neuromuscular junction (NMJ) and central synapses (1). Recently gene rearrangements involving MAST and Notch have been reported. Overexpression of MAST1 or MAST2 gene fusions plays an important effect on proliferative (2).

Reference
1. Garland, P., Quraishe, S., French, P. and O'Connor, V. (2008) Expression of the MAST family of serine/threonine kinases. Brain Res, 1195, 12-19. PMID: 18206861
2. Robinson, D.R., Kalyana-Sundaram, S., Wu, Y.M., Shankar, S., Cao, X., Ateeq, B., Asangani, I.A., Iyer, M., Maher, C.A., Grasso, C.S. et al. (2011) Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Nat Med, 17, 1646-1651 PMID: 22101766

  Reviewed (5)  or Unreviewed (0) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-HOS-00207	ENSG00000105613	MAST1; KIAA0973, SAST
2		EKS-HOS-00205	ENSG00000069020	MAST4; KIAA0303
3		EKS-HOS-00208	ENSG00000120539	GW, GWL, THC2; MASTL
4		EKS-HOS-00206	ENSG00000099308	MAST3; KIAA0561
5		EKS-HOS-00204	ENSG00000086015	KIAA0807, MAST205; MAST2