Ailuropoda melanoleuca      CMGC      MAPK

※ MAPK family introduction

    MAPK (mitogen-activated protein kinase) are serine/threonine specific protein kinases belonging to CMGC kinase group. MAPKs play an important role in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. MAPKs are involved in regulation of a variety of cellular processes, including cell proliferation, gene expression, differentiation, mitosis, cell survival and cell apoptosis. Three subfamilys constitute MAPK family, extracellular-receptor kinases (ERK), the c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK) and p38 MAPKinases. MAPK signaling pathways are important in animals, fungi and plants. ERK1/2 pathway is best understood in animals, which is essential for cell proliferation and cell cycle. Fus3 pathway is also well studied in fungi, which is responsible for cell cycle and mating in responses to pheromone stimulation. MAPKs pathway in plants may response to osmotic shock, oxidative stress, cold and anti-pathogen responses (1).

Reference
1. Wikipedia Annotation:    Mitogen-activated protein kinase


There are 14 genes.  Reviewed (0 or Unreviewed (14

No.StatusEKPD IDGene IDGene Name
1
EKS-AIM-00429
ENSAMEG00000000376
MAPK13
2
EKS-AIM-00428
ENSAMEG00000000425
MAPK14
3
EKS-AIM-00435
ENSAMEG00000008869
MAPK1; PANDA_015979
4
EKS-AIM-00441
ENSAMEG00000000233
5
EKS-AIM-00433
ENSAMEG00000017017
PANDA_014394; MAPK8
6
EKS-AIM-00434
ENSAMEG00000000853
MAPK9
7
EKS-AIM-00437
ENSAMEG00000005132
NLK
8
EKS-AIM-00440
ENSAMEG00000002977
MAPK4
9
EKS-AIM-00438
ENSAMEG00000006484
MAPK15
10
EKS-AIM-00431
ENSAMEG00000002468
MAPK11
11
EKS-AIM-00430
ENSAMEG00000002456
MAPK12
12
EKS-AIM-00436
ENSAMEG00000015300
MAPK3
13
EKS-AIM-00439
ENSAMEG00000007132
MAPK6; PANDA_013113
14
EKS-AIM-00432
ENSAMEG00000003514
MAPK10