※ MAPK family introduction

    MAPK (mitogen-activated protein kinase) are serine/threonine specific protein kinases belonging to CMGC kinase group. MAPKs play an important role in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. MAPKs are involved in regulation of a variety of cellular processes, including cell proliferation, gene expression, differentiation, mitosis, cell survival and cell apoptosis. Three subfamilys constitute MAPK family, extracellular-receptor kinases (ERK), the c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK) and p38 MAPKinases. MAPK signaling pathways are important in animals, fungi and plants. ERK1/2 pathway is best understood in animals, which is essential for cell proliferation and cell cycle. Fus3 pathway is also well studied in fungi, which is responsible for cell cycle and mating in responses to pheromone stimulation. MAPKs pathway in plants may response to osmotic shock, oxidative stress, cold and anti-pathogen responses (1).

Reference
1. Wikipedia Annotation:    Mitogen-activated protein kinase

  Reviewed (13)  or Unreviewed (1) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-MUM-00499	ENSMUSG00000001034	Mapk7; Bmk1, Erk5
2		EKS-MUM-00500	ENSMUSG00000017376	Nlk
3		EKS-MUM-00501	ENSMUSG00000063704	Mapk15; Erk7
4		EKS-MUM-00496	ENSMUSG00000020366	Mapk9; Jnk2, Prkm9
5		EKS-MUM-00503	ENSMUSG00000024558	Erk4, Prkm4; Mapk4
6		EKS-MUM-00497	ENSMUSG00000046709	Mapk10
7		EKS-MUM-00498	ENSMUSG00000021936	Mapk8; Jnk1, Prkm8
8		EKS-MUM-00491	ENSMUSG00000053137	Prkm11; Mapk11
9		EKS-MUM-00502	ENSMUSG00000042688	Erk3, Prkm4, Prkm6; Mapk6
10		EKS-MUM-00490	ENSMUSG00000053436	Mapk14; Crk1, Csbp1, Csbp2
11		EKS-MUM-00492	ENSMUSG00000022610	Mapk12; Sapk3
12		EKS-MUM-00495	ENSMUSG00000004864	Mapk13; Serk4
13		EKS-MUM-00493	ENSMUSG00000063065	Erk1, Prkm3; Mapk3
14		EKS-MUM-00494	ENSMUSG00000063358	Erk2, Mapk, Prkm1; Mapk1