※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

  Reviewed (1)  or Unreviewed (13) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-EQC-00010	ENSECAG00000011911	DUSP3
2		EPS-EQC-00012	ENSECAG00000021937	DUSP12
3		EPS-EQC-00013	ENSECAG00000017721	EPM2A
4		EPS-EQC-00002	ENSECAG00000020752	DUPD1
5		EPS-EQC-00005	ENSECAG00000003517	DUSP21
6		EPS-EQC-00004	ENSECAG00000005790	DUSP18
7		EPS-EQC-00003	ENSECAG00000015233	DUSP26
8		EPS-EQC-00011	ENSECAG00000017381	DUSP15
9		EPS-EQC-00015	ENSECAG00000024776	DUSP23
10		EPS-EQC-00008	ENSECAG00000003831	DUSP14
11		EPS-EQC-00006	ENSECAG00000000088	DUSP13
12		EPS-EQC-00014	ENSECAG00000023353	DUSP11
13		EPS-EQC-00007	ENSECAG00000000783	DUSP27
14		EPS-EQC-00009	ENSECAG00000014558	DUSP22