※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-MOD-00013	ENSMODG00000008388	DUSP22
2		EPS-MOD-00009	ENSMODG00000024437	DUSP14
3		EPS-MOD-00008	ENSMODG00000002519	DUSP27
4		EPS-MOD-00012	ENSMODG00000013459	DUSP28
5		EPS-MOD-00010	ENSMODG00000019482	DUSP15
6		EPS-MOD-00003	ENSMODG00000011051	DUSP26
7		EPS-MOD-00007	ENSMODG00000015202	DUSP3
8		EPS-MOD-00016	ENSMODG00000019914	PTPMT1
9		EPS-MOD-00018	ENSMODG00000018289	RNGTT
10		EPS-MOD-00017	ENSMODG00000010053	DUSP23
11		EPS-MOD-00002	ENSMODG00000000746	DUPD1
12		EPS-MOD-00004	ENSMODG00000000762	DUSP13
13		EPS-MOD-00005	ENSMODG00000009494	LOC100031156
14		EPS-MOD-00006	ENSMODG00000000853	LOC100617243
15		EPS-MOD-00015	ENSMODG00000016915	EPM2A
16		EPS-MOD-00011	ENSMODG00000000962	DUSP12
17		EPS-MOD-00014	ENSMODG00000010579	DUSP11