※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

  Reviewed (0)  or Unreviewed (10) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-CII-00181	ENSCING00000003555	LOC100177464; CIN.44693
2		EKS-CII-00185	ENSCING00000002706	CIN.47759
3		EKS-CII-00183	ENSCING00000009652
4		EKS-CII-00179	ENSCING00000009594
5		EKS-CII-00180	ENSCING00000009234	CIN.39371; Cin.25397
6		EKS-CII-00177	ENSCING00000005299	LOC100184515; CIN.43221
7		EKS-CII-00184	ENSCING00000006270
8		EKS-CII-00182	ENSCING00000020161
9		EKS-CII-00186	ENSCING00000007087	LOC100176369; CIN.12938
10		EKS-CII-00178	ENSCING00000007043