※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

  Reviewed (0)  or Unreviewed (27) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SUS-00278	ENSSSCG00000010606	SLK
2		EKS-SUS-00295	ENSSSCG00000022496
3		EKS-SUS-00288	ENSSSCG00000008164	MAP4K4
4		EKS-SUS-00273	ENSSSCG00000014878	LOC100525766; PAK1
5		EKS-SUS-00280	ENSSSCG00000004781	PAK6
6		EKS-SUS-00277	ENSSSCG00000021205	MST4
7		EKS-SUS-00282	ENSSSCG00000021333
8		EKS-SUS-00291	ENSSSCG00000009511	STK24
9		EKS-SUS-00284	ENSSSCG00000030520	PAK4
10		EKS-SUS-00286	ENSSSCG00000009850	TAOK3
11		EKS-SUS-00292	ENSSSCG00000017290	STRADA
12		EKS-SUS-00285	ENSSSCG00000017790	LOC100622172; TAOK1
13		EKS-SUS-00289	ENSSSCG00000012546
14		EKS-SUS-00274	ENSSSCG00000017917	MINK; MINK1
15		EKS-SUS-00276	ENSSSCG00000006074	STK3
16		EKS-SUS-00279	ENSSSCG00000013020	MAP4K2
17		EKS-SUS-00290	ENSSSCG00000028905
18		EKS-SUS-00296	ENSSSCG00000028432
19		EKS-SUS-00293	ENSSSCG00000011843	PAK2
20		EKS-SUS-00275	ENSSSCG00000016372	STK25
21		EKS-SUS-00298	ENSSSCG00000016996	STK10
22		EKS-SUS-00287	ENSSSCG00000011059	MYO3A
23		EKS-SUS-00283	ENSSSCG00000007061	PAK7
24		EKS-SUS-00281	ENSSSCG00000002962	MAP4K1
25		EKS-SUS-00294	ENSSSCG00000011253
26		EKS-SUS-00299	ENSSSCG00000011252	OXSR1
27		EKS-SUS-00297	ENSSSCG00000007386	STK4