※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TEN-00425	ENSTNIG00000016195	TAOK1
2		EKS-TEN-00415	ENSTNIG00000005218	STK4
3		EKS-TEN-00429	ENSTNIG00000016927	MYO3B
4		EKS-TEN-00422	ENSTNIG00000012747	OXSR1 (1 of 2)
5		EKS-TEN-00412	ENSTNIG00000004822	MAP4K2
6		EKS-TEN-00426	ENSTNIG00000004283	TAOK2 (2 of 2); TAOK2 (1 of 2)
7		EKS-TEN-00409	ENSTNIG00000017626	PAK2 (1 of 3)
8		EKS-TEN-00419	ENSTNIG00000006663	TNIK (1 of 2)
9		EKS-TEN-00435	ENSTNIG00000013323	SLK (1 of 2)
10		EKS-TEN-00408	ENSTNIG00000013280	STK24 (1 of 2)
11		EKS-TEN-00420	ENSTNIG00000006534	MAP4K1 (2 of 2); MAP4K1
12		EKS-TEN-00433	ENSTNIG00000006538	MAP4K2; MAP4K1 (1 of 2)
13		EKS-TEN-00430	ENSTNIG00000013640	MYO3A
14		EKS-TEN-00410	ENSTNIG00000009144	STK3
15		EKS-TEN-00407	ENSTNIG00000013983	STK24 (2 of 2)
16		EKS-TEN-00413	ENSTNIG00000009818	MAP4K3
17		EKS-TEN-00416	ENSTNIG00000010731	PAK7
18		EKS-TEN-00432	ENSTNIG00000014937	STRADA
19		EKS-TEN-00434	ENSTNIG00000010354	STRADB
20		EKS-TEN-00427	ENSTNIG00000018704	STK39
21		EKS-TEN-00404	ENSTNIG00000010047	PAK3
22		EKS-TEN-00403	ENSTNIG00000014520	MAP4K4 (2 of 2)
23		EKS-TEN-00417	ENSTNIG00000014256	STK10
24		EKS-TEN-00423	ENSTNIG00000014161	SLK (2 of 2)
25		EKS-TEN-00401	ENSTNIG00000002564	TNIK (2 of 2)
26		EKS-TEN-00411	ENSTNIG00000019335	MAP4K5
27		EKS-TEN-00405	ENSTNIG00000019429	PAK2 (3 of 3); GSTENG00013203001, GSTENG00035962001
28		EKS-TEN-00400	ENSTNIG00000011772	MINK1
29		EKS-TEN-00406	ENSTNIG00000006866	PAK2 (2 of 3)
30		EKS-TEN-00421	ENSTNIG00000006800	PAK4
31		EKS-TEN-00431	ENSTNIG00000015689	MAP4K4 (1 of 2)
32		EKS-TEN-00428	ENSTNIG00000015215	TAOK2 (2 of 2); TAOK2 (1 of 2)
33		EKS-TEN-00402	ENSTNIG00000003751	PAK1
34		EKS-TEN-00418	ENSTNIG00000007848	STK25
35		EKS-TEN-00424	ENSTNIG00000007922	OXSR1 (2 of 2)
36		EKS-TEN-00414	ENSTNIG00000011240