※ Eph family introduction

    Eph receptor tyrosine kinases are known able to bind their ephrin ligands and act as key regulator of cell contact-dependent signaling and patterning. Eph kinase contains fourteen members which can further be classified into two subclasses A and B in human. EphA1-8 and Eph10 belong to subclass A, EphB1-4 and EphB6 belong to subclass B. Eph kinases consist of two regions: intracellular region and extracellular region. The extracellular part contains a globular ligand-binding domain, a cysteine-rich region and two fibronectin type III repeats. The intracellular part contains a short juxtamembrane region, a kinase catalytic domain, a sterile α motif (SAM) protein−protein interaction domain and a PDZ-binding motif. Eph/ephrin binding will lead to very diverse biological readouts including adhesion versus repulsion and increased versus decreased motility. Depending on the different cell type and context, the interaction will lead to different downstream signaling pathway. In addition, evidence shows that endocytosis of Eph/ephrin and associated tissue-specific effectors are essential for diverse biological roles and processes (1).

Reference
1. Pitulescu, M.E. and Adams, R.H. (2010) Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev, 24, 2480-2492. PMID: 21078817

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-CAP-00012	ENSCPOG00000005313	EPHB6
2		EKS-CAP-00001	ENSCPOG00000011048	EPHA4
3		EKS-CAP-00009	ENSCPOG00000014707	EPHA1
4		EKS-CAP-00006	ENSCPOG00000014491	EPHB4
5		EKS-CAP-00013	ENSCPOG00000002021	EPHB1
6		EKS-CAP-00004	ENSCPOG00000010844	EPHB2
7		EKS-CAP-00002	ENSCPOG00000010060	EPHA5
8		EKS-CAP-00007	ENSCPOG00000003065	EPHA2
9		EKS-CAP-00003	ENSCPOG00000003600	EPHA7
10		EKS-CAP-00014	ENSCPOG00000003784
11		EKS-CAP-00010	ENSCPOG00000004479	EPHA10
12		EKS-CAP-00008	ENSCPOG00000021134	EPHA8
13		EKS-CAP-00011	ENSCPOG00000004938	EPHA3
14		EKS-CAP-00005	ENSCPOG00000000977	EPHB3