※ Eph family introduction

    Eph receptor tyrosine kinases are known able to bind their ephrin ligands and act as key regulator of cell contact-dependent signaling and patterning. Eph kinase contains fourteen members which can further be classified into two subclasses A and B in human. EphA1-8 and Eph10 belong to subclass A, EphB1-4 and EphB6 belong to subclass B. Eph kinases consist of two regions: intracellular region and extracellular region. The extracellular part contains a globular ligand-binding domain, a cysteine-rich region and two fibronectin type III repeats. The intracellular part contains a short juxtamembrane region, a kinase catalytic domain, a sterile α motif (SAM) protein−protein interaction domain and a PDZ-binding motif. Eph/ephrin binding will lead to very diverse biological readouts including adhesion versus repulsion and increased versus decreased motility. Depending on the different cell type and context, the interaction will lead to different downstream signaling pathway. In addition, evidence shows that endocytosis of Eph/ephrin and associated tissue-specific effectors are essential for diverse biological roles and processes (1).

Reference
1. Pitulescu, M.E. and Adams, R.H. (2010) Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev, 24, 2480-2492. PMID: 21078817

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-MYL-00010	ENSMLUG00000010142	EPHB4
2		EKS-MYL-00003	ENSMLUG00000002345	EPHA3
3		EKS-MYL-00008	ENSMLUG00000014723	EPHB3
4		EKS-MYL-00011	ENSMLUG00000014957	EPHA2
5		EKS-MYL-00001	ENSMLUG00000015777	EPHA4
6		EKS-MYL-00009	ENSMLUG00000015827	EPHA6
7		EKS-MYL-00013	ENSMLUG00000015118	EPHA1
8		EKS-MYL-00004	ENSMLUG00000005373	EPHA7
9		EKS-MYL-00014	ENSMLUG00000012236	EPHA10
10		EKS-MYL-00002	ENSMLUG00000025356	EPHB2
11		EKS-MYL-00006	ENSMLUG00000013071	EPHB1
12		EKS-MYL-00005	ENSMLUG00000003167
13		EKS-MYL-00012	ENSMLUG00000003124	EPHA8
14		EKS-MYL-00007	ENSMLUG00000002865	EPHA5