※ Eph family introduction

    Eph receptor tyrosine kinases are known able to bind their ephrin ligands and act as key regulator of cell contact-dependent signaling and patterning. Eph kinase contains fourteen members which can further be classified into two subclasses A and B in human. EphA1-8 and Eph10 belong to subclass A, EphB1-4 and EphB6 belong to subclass B. Eph kinases consist of two regions: intracellular region and extracellular region. The extracellular part contains a globular ligand-binding domain, a cysteine-rich region and two fibronectin type III repeats. The intracellular part contains a short juxtamembrane region, a kinase catalytic domain, a sterile α motif (SAM) protein−protein interaction domain and a PDZ-binding motif. Eph/ephrin binding will lead to very diverse biological readouts including adhesion versus repulsion and increased versus decreased motility. Depending on the different cell type and context, the interaction will lead to different downstream signaling pathway. In addition, evidence shows that endocytosis of Eph/ephrin and associated tissue-specific effectors are essential for diverse biological roles and processes (1).

Reference
1. Pitulescu, M.E. and Adams, R.H. (2010) Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev, 24, 2480-2492. PMID: 21078817

  Reviewed (0)  or Unreviewed (13) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TAG-00002	ENSTGUG00000004560	EPHA5
2		EKS-TAG-00006	ENSTGUG00000010386	EPHB3
3		EKS-TAG-00001	ENSTGUG00000007665	EPHA4
4		EKS-TAG-00010	ENSTGUG00000002048	EPHA2
5		EKS-TAG-00013	ENSTGUG00000006852	EPHB1
6		EKS-TAG-00012	ENSTGUG00000001509	EPHA10
7		EKS-TAG-00007	ENSTGUG00000017239	EPHA8
8		EKS-TAG-00009	ENSTGUG00000017194	EPHB2
9		EKS-TAG-00004	ENSTGUG00000013491	EPHA3
10		EKS-TAG-00005	ENSTGUG00000013496	EPHA6
11		EKS-TAG-00011	ENSTGUG00000013242	EPHA1
12		EKS-TAG-00008	ENSTGUG00000013187	EPHB6
13		EKS-TAG-00003	ENSTGUG00000012333	EPHA7