※ FGFR family introduction

    FGFR (Fibroblast growth factor receptor) are receptor tyrosine protein kinase and involved in FGF signaling. FGFRs contain an extracellular domain which can directly bind to FGF ligand, a transmembrane and intracellular ��split-kinase�� domain. The combining of extracellular domain and ligand will lead to the phosphorylation of several tyrosine residues within their intracellular domains and this will increase the kinase activity of FGFRs. Activated FGFRs can interact with downstream molecules, such as PLC��-1 and Crk and activate related signaling cascades pathway, which regulate distinct biological process including proliferation, differentiation, cell survival, protein synthesis, angiogenesis, cell growth and cell migration (1).

Reference
1. Acevedo, V.D., Ittmann, M. and Spencer, D.M. (2009) Paths of FGFR-driven tumorigenesis. Cell Cycle, 8, 580-588. PMID: 19182515

  Reviewed (2)  or Unreviewed (2) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-MUM-00154	ENSMUSG00000005320	Fgfr-4, Mpk-11; Fgfr4
2		EKS-MUM-00153	ENSMUSG00000031565	Fgfr1; Flg
3		EKS-MUM-00151	ENSMUSG00000030849	Fgfr2
4		EKS-MUM-00152	ENSMUSG00000054252	Fgfr3