※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-LAC-00393	ENSLACG00000018827	MAP3K10
2		EKS-LAC-00399	ENSLACG00000006027	ILK
3		EKS-LAC-00398	ENSLACG00000003330	MAP3K12
4		EKS-LAC-00394	ENSLACG00000003510
5		EKS-LAC-00395	ENSLACG00000009835
6		EKS-LAC-00396	ENSLACG00000009829	MAP3K7
7		EKS-LAC-00397	ENSLACG00000009593	MAP3K11
8		EKS-LAC-00392	ENSLACG00000008405	MAP3K9
9		EKS-LAC-00391	ENSLACG00000005057