※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-OTG-00387	ENSOGAG00000011573
2		EKS-OTG-00383	ENSOGAG00000001739	MAP3K12
3		EKS-OTG-00380	ENSOGAG00000013974	MAP3K10
4		EKS-OTG-00385	ENSOGAG00000014054
5		EKS-OTG-00378	ENSOGAG00000014085	MAP3K11
6		EKS-OTG-00381	ENSOGAG00000010128
7		EKS-OTG-00382	ENSOGAG00000014223	MAP3K13
8		EKS-OTG-00384	ENSOGAG00000006039	MAP3K7
9		EKS-OTG-00379	ENSOGAG00000011147	MAP3K9
10		EKS-OTG-00386	ENSOGAG00000007187	ILK