※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SAH-00348	ENSSHAG00000007265	MAP3K12
2		EKS-SAH-00354	ENSSHAG00000018555
3		EKS-SAH-00347	ENSSHAG00000008034
4		EKS-SAH-00352	ENSSHAG00000003972	MAP3K11
5		EKS-SAH-00355	ENSSHAG00000018491
6		EKS-SAH-00346	ENSSHAG00000013384
7		EKS-SAH-00349	ENSSHAG00000017677	MAP3K7
8		EKS-SAH-00351	ENSSHAG00000009423	ILK
9		EKS-SAH-00350	ENSSHAG00000005927
10		EKS-SAH-00353	ENSSHAG00000012566	MAP3K13