※ DMPK family introduction

    DMPK (myotonic dystrophy protein kinase) belong to AGC family, which was first described in 1909 to have relation with myotonic dystrophy. The phylogenetic tree of DMPK family shows this family also includes ROCKs (Rho kinases), MRCK (cell division control protein 42 (Cdc42)-binding kinases) and citron kinase. Sequence analysis shows that these kinases contain an amino-terminal kinase catalytic domain followed by a coiled-coil-forming region and other functional motifs at the C-terminus. DMPK have been probed by synthetic peptides or putative physiological substrates to possess Serine/Threonine kinase activity, many proteins targeted by DMPK show a consensus motif R x x S/T L/V R, which is similar to PKC. DMPK have been shown to act as a key molecule in regulation these in varieties of cellular processes, including regulation of skeletal muscle proper structure and function, ion-channel gating control and cell metabolism. In addition, abnormal expression or genetic defect of DMPK associated with myotonic dystrophy 1 (1).

Reference
1. Kaliman, P. and Llagostera, E. (2008) Myotonic dystrophy protein kinase (DMPK) and its role in the pathogenesis of myotonic dystrophy 1. Cell Signal, 20, 1935-1941. PMID: 18583094

  Reviewed (5)  or Unreviewed (2) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-MUM-00475	ENSMUSG00000020580	Rock2
2		EKS-MUM-00474	ENSMUSG00000024290	Rock1
3		EKS-MUM-00477	ENSMUSG00000029516	Cit
4		EKS-MUM-00473	ENSMUSG00000024769	Cdc42bpg
5		EKS-MUM-00472	ENSMUSG00000021279	Kiaa1124; Cdc42bpb
6		EKS-MUM-00476	ENSMUSG00000030409	Dm15, Mdpk; Dmpk
7		EKS-MUM-00471	ENSMUSG00000026490	Kiaa0451; Cdc42bpa