※ PKC family introduction

    PKC (protein kinase C) belong to AGC family. PKC can be subgrouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and activated by different lipids. The atypical PKCs is smallest in size in all PKCs, they are activated dephend on PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, modulating membrane structure, regulating transcription, mediating immune responses, regulating cell growth and learning and memory (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TAR-00226	ENSTRUG00000011406	PRKCH
2		EKS-TAR-00228	ENSTRUG00000011933	PRKCQ
3		EKS-TAR-00229	ENSTRUG00000005119	PRKCD (2 of 2); PRKCD (1 of 2)
4		EKS-TAR-00220	ENSTRUG00000000911	PRKCA (1 of 2)
5		EKS-TAR-00224	ENSTRUG00000005596	PRKCI
6		EKS-TAR-00223	ENSTRUG00000004772	PRKCE (2 of 2)
7		EKS-TAR-00222	ENSTRUG00000000339	PRKCE (1 of 2)
8		EKS-TAR-00225	ENSTRUG00000004569	PRKCG
9		EKS-TAR-00221	ENSTRUG00000016241	PRKCA (2 of 2)
10		EKS-TAR-00218	ENSTRUG00000009582	PRKCB (1 of 2)
11		EKS-TAR-00219	ENSTRUG00000010099	PRKCB (2 of 2)
12		EKS-TAR-00227	ENSTRUG00000010650	PRKCD (2 of 2); PRKCD (1 of 2)