※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-CAF-00016	ENSCAFG00000030984	DUSP22
2		EPS-CAF-00023	ENSCAFG00000008439
3		EPS-CAF-00018	ENSCAFG00000013058	DUSP12
4		EPS-CAF-00011	ENSCAFG00000014525	DUSP21
5		EPS-CAF-00021	ENSCAFG00000032426	PTPMT1
6		EPS-CAF-00009	ENSCAFG00000029801	DUSP26
7		EPS-CAF-00024	ENSCAFG00000031934	DUSP23
8		EPS-CAF-00013	ENSCAFG00000028570	DUSP3
9		EPS-CAF-00012	ENSCAFG00000012837	DUSP18
10		EPS-CAF-00014	ENSCAFG00000015574	DUSP27
11		EPS-CAF-00022	ENSCAFG00000031410	STYX
12		EPS-CAF-00010	ENSCAFG00000031398	DUSP13
13		EPS-CAF-00015	ENSCAFG00000018142	DUSP14
14		EPS-CAF-00020	ENSCAFG00000008797	DUSP11
15		EPS-CAF-00017	ENSCAFG00000031031	DUSP15
16		EPS-CAF-00019	ENSCAFG00000000329	EPM2A
17		EPS-CAF-00025	ENSCAFG00000003089	RNGTT