※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-GOG-00010	ENSGGOG00000004395	DUSP18
2		EPS-GOG-00014	ENSGGOG00000004523	DUSP27
3		EPS-GOG-00019	ENSGGOG00000004596	DUSP12
4		EPS-GOG-00015	ENSGGOG00000024300	DUSP14
5		EPS-GOG-00022	ENSGGOG00000014958	DUSP23
6		EPS-GOG-00020	ENSGGOG00000010122	DUSP11
7		EPS-GOG-00016	ENSGGOG00000004744	DUSP22
8		EPS-GOG-00018	ENSGGOG00000011846	DUSP15
9		EPS-GOG-00011	ENSGGOG00000011021	DUSP13
10		EPS-GOG-00017	ENSGGOG00000011019	DUPD1
11		EPS-GOG-00009	ENSGGOG00000014340	DUSP26
12		EPS-GOG-00013	ENSGGOG00000014141	DUSP21
13		EPS-GOG-00012	ENSGGOG00000023681	DUSP3
14		EPS-GOG-00021	ENSGGOG00000013954	PTPMT1