※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM), includes protein phosphatases which dependent on manganese/magnesium ions (Mn2+/Mg2+). PPM family contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determine the substrate recognition and function diversity. Like PPP family, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is the largest protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor proteins (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (13) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-ORA-00022	ENSOANG00000011523	PPM1D
2		EPS-ORA-00021	ENSOANG00000015598	ILKAP
3		EPS-ORA-00020	ENSOANG00000006156	PPM1B
4		EPS-ORA-00023	ENSOANG00000008495	PPM1E
5		EPS-ORA-00024	ENSOANG00000008185	PHLPP2
6		EPS-ORA-00030	ENSOANG00000014788	PPM1H
7		EPS-ORA-00027	ENSOANG00000004988	PP2D1
8		EPS-ORA-00029	ENSOANG00000004965	PPM1M
9		EPS-ORA-00001	ENSOANG00000004786	PPTC7
10		EPS-ORA-00028	ENSOANG00000002615	PPM1J
11		EPS-ORA-00025	ENSOANG00000013295	PPM1G
12		EPS-ORA-00019	ENSOANG00000011857	PPM1A
13		EPS-ORA-00026	ENSOANG00000008982	PPM1L