※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ORA-00291	ENSOANG00000009204	PAK2
2		EKS-ORA-00293	ENSOANG00000009651	LOC100092939
3		EKS-ORA-00287	ENSOANG00000009606	STRADB
4		EKS-ORA-00272	ENSOANG00000005462	STK24
5		EKS-ORA-00295	ENSOANG00000009960	STRADA
6		EKS-ORA-00270	ENSOANG00000009867	PAK1
7		EKS-ORA-00276	ENSOANG00000013669	LOC100088971
8		EKS-ORA-00290	ENSOANG00000000504	MAP4K1
9		EKS-ORA-00285	ENSOANG00000000384	OXSR1
10		EKS-ORA-00274	ENSOANG00000013975	NIN
11		EKS-ORA-00294	ENSOANG00000021216
12		EKS-ORA-00289	ENSOANG00000013101	STK4
13		EKS-ORA-00271	ENSOANG00000002406	PAK3
14		EKS-ORA-00286	ENSOANG00000012684	TNIK
15		EKS-ORA-00279	ENSOANG00000012648	TAOK1
16		EKS-ORA-00281	ENSOANG00000006026	MYO3A
17		EKS-ORA-00283	ENSOANG00000014972	MAP4K3
18		EKS-ORA-00275	ENSOANG00000011646	NRK
19		EKS-ORA-00284	ENSOANG00000002852	STK3
20		EKS-ORA-00273	ENSOANG00000011756	STK25
21		EKS-ORA-00288	ENSOANG00000011701	LOC100084337
22		EKS-ORA-00282	ENSOANG00000008553	MYO3B
23		EKS-ORA-00277	ENSOANG00000008420	PAK7
24		EKS-ORA-00278	ENSOANG00000008490	STK39
25		EKS-ORA-00280	ENSOANG00000008236	MAP4K4
26		EKS-ORA-00292	ENSOANG00000010956	LOC100088453