※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TEN-00487	ENSTNIG00000016247	ILK (1 of 2); ILK
2		EKS-TEN-00480	ENSTNIG00000016461	MAP3K13
3		EKS-TEN-00483	ENSTNIG00000016945
4		EKS-TEN-00481	ENSTNIG00000012586	MAP3K12 (2 of 2); MAP3K12 (1 of 2)
5		EKS-TEN-00489	ENSTNIG00000017006
6		EKS-TEN-00488	ENSTNIG00000009956	ILK (2 of 2)
7		EKS-TEN-00484	ENSTNIG00000005581	MAP3K7
8		EKS-TEN-00485	ENSTNIG00000010698	FPGT-TNNI3K
9		EKS-TEN-00482	ENSTNIG00000014828	MAP3K12 (2 of 2); MAP3K12 (1 of 2)
10		EKS-TEN-00478	ENSTNIG00000019348	MAP3K9
11		EKS-TEN-00477	ENSTNIG00000003891	MAP3K11
12		EKS-TEN-00486	ENSTNIG00000011097
13		EKS-TEN-00479	ENSTNIG00000007738	MAP3K10