※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-LOA-00289	ENSLAFG00000022543	ACVR1C
2		EKS-LOA-00294	ENSLAFG00000003785	TGFBR2
3		EKS-LOA-00290	ENSLAFG00000005832	BMPR1A
4		EKS-LOA-00287	ENSLAFG00000006865	ACVR1
5		EKS-LOA-00296	ENSLAFG00000018046	AMHR2
6		EKS-LOA-00293	ENSLAFG00000001488	ACVR2B
7		EKS-LOA-00295	ENSLAFG00000015201	BMPR2
8		EKS-LOA-00286	ENSLAFG00000003306	ACVR1B
9		EKS-LOA-00291	ENSLAFG00000008019	ACVRL1
10		EKS-LOA-00288	ENSLAFG00000010753	BMPR1B
11		EKS-LOA-00292	ENSLAFG00000002628	ACVR2A
12		EKS-LOA-00285	ENSLAFG00000008572	TGFBR1