※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-NOL-00012	ENSNLEG00000014783	DUSP27
2		EPS-NOL-00021	ENSNLEG00000006420	DUSP19
3		EPS-NOL-00019	ENSNLEG00000014681	PTPMT1; NDUFS3
4		EPS-NOL-00015	ENSNLEG00000009704	DUSP15
5		EPS-NOL-00007	ENSNLEG00000012120	DUSP26
6		EPS-NOL-00010	ENSNLEG00000019042	DUSP21
7		EPS-NOL-00013	ENSNLEG00000002727	DUSP14
8		EPS-NOL-00014	ENSNLEG00000010621	DUSP22
9		EPS-NOL-00018	ENSNLEG00000000306	DUSP11
10		EPS-NOL-00020	ENSNLEG00000013271	DUSP23
11		EPS-NOL-00008	ENSNLEG00000018918	DUSP18
12		EPS-NOL-00011	ENSNLEG00000005702	DUSP3
13		EPS-NOL-00016	ENSNLEG00000014515	DUSP12
14		EPS-NOL-00017	ENSNLEG00000015203	EPM2A
15		EPS-NOL-00009	ENSNLEG00000016844	DUSP13
16		EPS-NOL-00006	ENSNLEG00000016840	DUPD1