※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM), includes protein phosphatases which dependent on manganese/magnesium ions (Mn2+/Mg2+). PPM family contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determine the substrate recognition and function diversity. Like PPP family, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is the largest protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor proteins (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (18) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-SUS-00025	ENSSSCG00000011434	PPM1M
2		EPS-SUS-00027	ENSSSCG00000026665	PPM1D
3		EPS-SUS-00031	ENSSSCG00000025398	LOC100622965
4		EPS-SUS-00016	ENSSSCG00000005084	PPM1A
5		EPS-SUS-00001	ENSSSCG00000009825	PPTC7
6		EPS-SUS-00021	ENSSSCG00000010079	PPM1F
7		EPS-SUS-00020	ENSSSCG00000002739	LOC100626286; PHLPP2
8		EPS-SUS-00032	ENSSSCG00000021558
9		EPS-SUS-00029	ENSSSCG00000006774	PPM1J
10		EPS-SUS-00023	ENSSSCG00000027135	PPM1G
11		EPS-SUS-00030	ENSSSCG00000029004
12		EPS-SUS-00018	ENSSSCG00000016339	ILKAP
13		EPS-SUS-00019	ENSSSCG00000004896	PHLPP1
14		EPS-SUS-00022	ENSSSCG00000023434	PPM1L
15		EPS-SUS-00028	ENSSSCG00000000087	TAB1
16		EPS-SUS-00017	ENSSSCG00000008451	PPM1B
17		EPS-SUS-00024	ENSSSCG00000030397	PPM1D
18		EPS-SUS-00026	ENSSSCG00000027327	PP2D1