※ Eph family introduction

    Eph receptor tyrosine kinases are known able to bind their ephrin ligands and act as key regulator of cell contact-dependent signaling and patterning. Eph kinase contains fourteen members which can further be classified into two subclasses A and B in human. EphA1-8 and Eph10 belong to subclass A, EphB1-4 and EphB6 belong to subclass B. Eph kinases consist of two regions: intracellular region and extracellular region. The extracellular part contains a globular ligand-binding domain, a cysteine-rich region and two fibronectin type III repeats. The intracellular part contains a short juxtamembrane region, a kinase catalytic domain, a sterile α motif (SAM) protein−protein interaction domain and a PDZ-binding motif. Eph/ephrin binding will lead to very diverse biological readouts including adhesion versus repulsion and increased versus decreased motility. Depending on the different cell type and context, the interaction will lead to different downstream signaling pathway. In addition, evidence shows that endocytosis of Eph/ephrin and associated tissue-specific effectors are essential for diverse biological roles and processes (1).

Reference
1. Pitulescu, M.E. and Adams, R.H. (2010) Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev, 24, 2480-2492. PMID: 21078817

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ORA-00007	ENSOANG00000014567	EPHB4
2		EKS-ORA-00003	ENSOANG00000000485	EPHA3
3		EKS-ORA-00009	ENSOANG00000002050
4		EKS-ORA-00012	ENSOANG00000020317
5		EKS-ORA-00010	ENSOANG00000020066
6		EKS-ORA-00011	ENSOANG00000030330
7		EKS-ORA-00005	ENSOANG00000003700	EPHB3
8		EKS-ORA-00002	ENSOANG00000003966	EPHA5
9		EKS-ORA-00006	ENSOANG00000007540	EPHA6
10		EKS-ORA-00008	ENSOANG00000015001	EPHA2
11		EKS-ORA-00004	ENSOANG00000008930	EPHA7
12		EKS-ORA-00001	ENSOANG00000010961	EPHA4