※ Eph family introduction

    Eph receptor tyrosine kinases are known able to bind their ephrin ligands and act as key regulator of cell contact-dependent signaling and patterning. Eph kinase contains fourteen members which can further be classified into two subclasses A and B in human. EphA1-8 and Eph10 belong to subclass A, EphB1-4 and EphB6 belong to subclass B. Eph kinases consist of two regions: intracellular region and extracellular region. The extracellular part contains a globular ligand-binding domain, a cysteine-rich region and two fibronectin type III repeats. The intracellular part contains a short juxtamembrane region, a kinase catalytic domain, a sterile α motif (SAM) protein−protein interaction domain and a PDZ-binding motif. Eph/ephrin binding will lead to very diverse biological readouts including adhesion versus repulsion and increased versus decreased motility. Depending on the different cell type and context, the interaction will lead to different downstream signaling pathway. In addition, evidence shows that endocytosis of Eph/ephrin and associated tissue-specific effectors are essential for diverse biological roles and processes (1).

Reference
1. Pitulescu, M.E. and Adams, R.H. (2010) Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev, 24, 2480-2492. PMID: 21078817

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SAH-00002	ENSSHAG00000002306	EPHA3
2		EKS-SAH-00007	ENSSHAG00000007881	EPHB4
3		EKS-SAH-00010	ENSSHAG00000014595	EPHA8
4		EKS-SAH-00006	ENSSHAG00000008131	EPHB3
5		EKS-SAH-00011	ENSSHAG00000013395	EPHA10
6		EKS-SAH-00005	ENSSHAG00000013476	EPHB1
7		EKS-SAH-00012	ENSSHAG00000004627	EPHB6
8		EKS-SAH-00001	ENSSHAG00000017781	EPHA4
9		EKS-SAH-00003	ENSSHAG00000017029	EPHA5
10		EKS-SAH-00004	ENSSHAG00000012536	EPHB2
11		EKS-SAH-00008	ENSSHAG00000011625	EPHA2
12		EKS-SAH-00009	ENSSHAG00000006808	EPHA1