※ Eph family introduction

    Eph receptor tyrosine kinases are known able to bind their ephrin ligands and act as key regulator of cell contact-dependent signaling and patterning. Eph kinase contains fourteen members which can further be classified into two subclasses A and B in human. EphA1-8 and Eph10 belong to subclass A, EphB1-4 and EphB6 belong to subclass B. Eph kinases consist of two regions: intracellular region and extracellular region. The extracellular part contains a globular ligand-binding domain, a cysteine-rich region and two fibronectin type III repeats. The intracellular part contains a short juxtamembrane region, a kinase catalytic domain, a sterile α motif (SAM) protein−protein interaction domain and a PDZ-binding motif. Eph/ephrin binding will lead to very diverse biological readouts including adhesion versus repulsion and increased versus decreased motility. Depending on the different cell type and context, the interaction will lead to different downstream signaling pathway. In addition, evidence shows that endocytosis of Eph/ephrin and associated tissue-specific effectors are essential for diverse biological roles and processes (1).

Reference
1. Pitulescu, M.E. and Adams, R.H. (2010) Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev, 24, 2480-2492. PMID: 21078817

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SUS-00005	ENSSSCG00000026516	LOC100514541; EPHB3
2		EKS-SUS-00010	ENSSSCG00000008919	EPHA5
3		EKS-SUS-00003	ENSSSCG00000004336	EPHA7
4		EKS-SUS-00002	ENSSSCG00000026130	EPHA3
5		EKS-SUS-00009	ENSSSCG00000016459	EPHA1
6		EKS-SUS-00012	ENSSSCG00000016473	EPHB6
7		EKS-SUS-00001	ENSSSCG00000016230	EPHA4; EphA4
8		EKS-SUS-00011	ENSSSCG00000023488	LOC100737487
9		EKS-SUS-00004	ENSSSCG00000003527	EPHB2
10		EKS-SUS-00008	ENSSSCG00000003523	EPHA8
11		EKS-SUS-00007	ENSSSCG00000003471	EPHA2
12		EKS-SUS-00006	ENSSSCG00000007675	EPHB4