※ FGFR family introduction

    FGFR (Fibroblast growth factor receptor) are receptor tyrosine protein kinase and involved in FGF signaling. FGFRs contain an extracellular domain which can directly bind to FGF ligand, a transmembrane and intracellular ��split-kinase�� domain. The combining of extracellular domain and ligand will lead to the phosphorylation of several tyrosine residues within their intracellular domains and this will increase the kinase activity of FGFRs. Activated FGFRs can interact with downstream molecules, such as PLC��-1 and Crk and activate related signaling cascades pathway, which regulate distinct biological process including proliferation, differentiation, cell survival, protein synthesis, angiogenesis, cell growth and cell migration (1).

Reference
1. Acevedo, V.D., Ittmann, M. and Spencer, D.M. (2009) Paths of FGFR-driven tumorigenesis. Cell Cycle, 8, 580-588. PMID: 19182515

  Reviewed (1)  or Unreviewed (4) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-DAR-00435	ENSDARG00000069105	fgfr4
2		EKS-DAR-00432	ENSDARG00000058115	fgfr2
3		EKS-DAR-00431	ENSDARG00000004782	fgfr3
4		EKS-DAR-00433	ENSDARG00000011027	fgfr1a; fgfr1; si:ch211-198o12.1
5		EKS-DAR-00434	ENSDARG00000011190	fgfr1b