※ PDGFR family introduction

    PDGFR (Platelet-derived growth factor receptor) are receptor tyrosine kinase. Two different gene encoding PDGFR-A and PDGFR-B have been identified in human genome, both of which can interact with PDGFs to regulate diverse cellular processes. PDGFRs contain similar structure, including five extracellular immunoglobulin loops and an intracellular kinase domain. PDGFRs are original inactive in unstimulated cell environment. Ligand binding leads to the dimerization of PDGFR which will mediate the autophosphorylation on tyrosine residues in intracellular domain. Activate PDGFR subsequently target the downstream signaling molecules via the docking sites and further lead to the protein-protein interactions. Via targeting to distinct molecules, PDGFRs are involved in diverse signaling pathway, including JNK/SAPK and RAS/MAPK, and some secondary effectors such as Akt, JNK, PKC and p70S6K (1).

Reference
1. Andrae, J., Gallini, R. and Betsholtz, C. (2008) Role of platelet-derived growth factors in physiology and medicine. Genes Dev, 22, 1276-1312. PMID: 18483217

  Reviewed (0)  or Unreviewed (5) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GAG-00341	ENSGALG00000013925	KIT
2		EKS-GAG-00339	ENSGALG00000013929	PDGFRA
3		EKS-GAG-00340	ENSGALG00000021313	PDGFRB
4		EKS-GAG-00343	ENSGALG00000017093	FLT3
5		EKS-GAG-00342	ENSGALG00000005725	CSF1R