※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.

  Reviewed (0)  or Unreviewed (14) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GAA-00445	ENSGACG00000010180	FYN
2		EKS-GAA-00452	ENSGACG00000014381	LYN
3		EKS-GAA-00446	ENSGACG00000006450
4		EKS-GAA-00454	ENSGACG00000006319	FRK
5		EKS-GAA-00450	ENSGACG00000011349	SRC (1 of 2)
6		EKS-GAA-00451	ENSGACG00000003658	HCK
7		EKS-GAA-00456	ENSGACG00000010799	BLK
8		EKS-GAA-00457	ENSGACG00000010298	SRMS
9		EKS-GAA-00458	ENSGACG00000010303	PTK6
10		EKS-GAA-00453	ENSGACG00000007232	LCK
11		EKS-GAA-00455	ENSGACG00000004157	YES1 (2 of 2)
12		EKS-GAA-00448	ENSGACG00000017071	YES1 (1 of 2)
13		EKS-GAA-00447	ENSGACG00000005767
14		EKS-GAA-00449	ENSGACG00000005548	SRC (2 of 2)