※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-PAT-00260	ENSPTRG00000021182	TGFBR1; ENSG00000106799
2		EKS-PAT-00268	ENSPTRG00000014711	ENSG00000163513; TGFBR2
3		EKS-PAT-00267	ENSPTRG00000014760	ACVR2B; ENSG00000114739
4		EKS-PAT-00271	ENSPTRG00000005015	AMHR2; ENSG00000135409
5		EKS-PAT-00270	ENSPTRG00000004964	ACVR1B; ENSG00000135503
6		EKS-PAT-00265	ENSPTRG00000004963	ACVRL1; ENSG00000139567
7		EKS-PAT-00263	ENSPTRG00000016293	ENSG00000138696; BMPR1B
8		EKS-PAT-00269	ENSPTRG00000029076	ENSG00000204217; BMPR2
9		EKS-PAT-00266	ENSPTRG00000012514	ACVR2A; ENSG00000121989
10		EKS-PAT-00261	ENSPTRG00000012555	ENSG00000115170; ACVR1
11		EKS-PAT-00262	ENSPTRG00000012554	ENSG00000123612; ACVR1C
12		EKS-PAT-00264	ENSPTRG00000002706	LOC745829; ENSG00000107779; BMPR1A