※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-POA-00274	ENSPPYG00000014006	ACVR2B
2		EKS-POA-00275	ENSPPYG00000014049	TGFBR2
3		EKS-POA-00270	ENSPPYG00000002270	BMPR1A
4		EKS-POA-00267	ENSPPYG00000019439	TGFBR1
5		EKS-POA-00272	ENSPPYG00000014938	BMPR1B
6		EKS-POA-00268	ENSPPYG00000004535	ACVR1B
7		EKS-POA-00271	ENSPPYG00000004534	ACVRL1
8		EKS-POA-00278	ENSPPYG00000004580	AMHR2
9		EKS-POA-00276	ENSPPYG00000013085	BMPR2
10		EKS-POA-00269	ENSPPYG00000012865	ACVR1
11		EKS-POA-00277	ENSPPYG00000012864	ACVR1C
12		EKS-POA-00273	ENSPPYG00000012834	ACVR2A