Bos taurus      CMGC      MAPK

※ MAPK family introduction

    MAPK (mitogen-activated protein kinase) are serine/threonine specific protein kinases belonging to CMGC kinase group. MAPKs play an important role in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. MAPKs are involved in regulation of a variety of cellular processes, including cell proliferation, gene expression, differentiation, mitosis, cell survival and cell apoptosis. Three subfamilys constitute MAPK family, extracellular-receptor kinases (ERK), the c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK) and p38 MAPKinases. MAPK signaling pathways are important in animals, fungi and plants. ERK1/2 pathway is best understood in animals, which is essential for cell proliferation and cell cycle. Fus3 pathway is also well studied in fungi, which is responsible for cell cycle and mating in responses to pheromone stimulation. MAPKs pathway in plants may response to osmotic shock, oxidative stress, cold and anti-pathogen responses (1).

Reference
1. Wikipedia Annotation:    Mitogen-activated protein kinase


There are 14 genes.  Reviewed (2 or Unreviewed (12

No.StatusEKPD IDGene IDGene Name
1
EKS-BOT-00470
ENSBTAG00000019864
BT.41192; MAPK15
2
EKS-BOT-00465
ENSBTAG00000007876
MAPK8
3
EKS-BOT-00464
ENSBTAG00000020048
MAPK10
4
EKS-BOT-00463
ENSBTAG00000010007
MAPK13
5
EKS-BOT-00467
ENSBTAG00000010312
MAPK1; ERK2, PRKM1
6
EKS-BOT-00469
ENSBTAG00000014825
NLK
7
EKS-BOT-00460
ENSBTAG00000020783
MAPK14
8
EKS-BOT-00461
ENSBTAG00000019574
MAPK12
9
EKS-BOT-00471
ENSBTAG00000005865
MAPK6
10
EKS-BOT-00468
ENSBTAG00000001014
MAPK7
11
EKS-BOT-00473
ENSBTAG00000004709
MAPK9
12
EKS-BOT-00466
ENSBTAG00000030182
BT.40394; MAPK11
13
EKS-BOT-00462
ENSBTAG00000016156
MAPK3
14
EKS-BOT-00472
ENSBTAG00000009907
MAPK4