※ MAPK family introduction

    MAPK (mitogen-activated protein kinase) are serine/threonine specific protein kinases belonging to CMGC kinase group. MAPKs play an important role in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. MAPKs are involved in regulation of a variety of cellular processes, including cell proliferation, gene expression, differentiation, mitosis, cell survival and cell apoptosis. Three subfamilys constitute MAPK family, extracellular-receptor kinases (ERK), the c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK) and p38 MAPKinases. MAPK signaling pathways are important in animals, fungi and plants. ERK1/2 pathway is best understood in animals, which is essential for cell proliferation and cell cycle. Fus3 pathway is also well studied in fungi, which is responsible for cell cycle and mating in responses to pheromone stimulation. MAPKs pathway in plants may response to osmotic shock, oxidative stress, cold and anti-pathogen responses (1).

Reference
1. Wikipedia Annotation:    Mitogen-activated protein kinase

  Reviewed (2)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-CAF-00470	ENSCAFG00000015640	MAPK6
2		EKS-CAF-00462	ENSCAFG00000000685	MAPK12
3		EKS-CAF-00460	ENSCAFG00000015421	MAPK1
4		EKS-CAF-00464	ENSCAFG00000000395	MAPK9
5		EKS-CAF-00463	ENSCAFG00000009396	MAPK10
6		EKS-CAF-00471	ENSCAFG00000013287	MAPK4
7		EKS-CAF-00472	ENSCAFG00000018974	MAPK3
8		EKS-CAF-00468	ENSCAFG00000018650	NLK_CANFA; NLK
9		EKS-CAF-00467	ENSCAFG00000018202	MAPK7
10		EKS-CAF-00465	ENSCAFG00000017108	MAPK3
11		EKS-CAF-00466	ENSCAFG00000006551	MAPK8
12		EKS-CAF-00469	ENSCAFG00000001338	MAPK15
13		EKS-CAF-00459	ENSCAFG00000001378	MK14_CANFA; MAPK14; CSBP1, CSBP2
14		EKS-CAF-00461	ENSCAFG00000001382	MAPK13