※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ORN-00477	ENSONIG00000009035	LYN
2		EKS-ORN-00472	ENSONIG00000009199	YES1 (2 of 2)
3		EKS-ORN-00476	ENSONIG00000016547	SRC (1 of 2)
4		EKS-ORN-00480	ENSONIG00000008194	LCK
5		EKS-ORN-00471	ENSONIG00000011372	LOC100690757
6		EKS-ORN-00481	ENSONIG00000011345	FRK
7		EKS-ORN-00479	ENSONIG00000015333	BLK
8		EKS-ORN-00482	ENSONIG00000014862	SRMS
9		EKS-ORN-00473	ENSONIG00000002248	LOC100697412
10		EKS-ORN-00475	ENSONIG00000006882	SRC (2 of 2)
11		EKS-ORN-00474	ENSONIG00000006089	YES1 (1 of 2)
12		EKS-ORN-00470	ENSONIG00000001335	FYN
13		EKS-ORN-00478	ENSONIG00000000464	HCK