※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.

  Reviewed (0)  or Unreviewed (14) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ORL-00442	ENSORLG00000017982	FRK
2		EKS-ORL-00432	ENSORLG00000013453	FYN
3		EKS-ORL-00444	ENSORLG00000020286	PTK6
4		EKS-ORL-00445	ENSORLG00000020271	SRMS
5		EKS-ORL-00434	ENSORLG00000017875	YES1 (2 of 2)
6		EKS-ORL-00441	ENSORLG00000017495	LCK
7		EKS-ORL-00439	ENSORLG00000012708	LYN
8		EKS-ORL-00443	ENSORLG00000016355	BLK
9		EKS-ORL-00436	ENSORLG00000016183	SRC (1 of 2)
10		EKS-ORL-00437	ENSORLG00000011192	YES1 (1 of 2)
11		EKS-ORL-00433	ENSORLG00000011084
12		EKS-ORL-00440	ENSORLG00000002368	HCK
13		EKS-ORL-00438	ENSORLG00000018018
14		EKS-ORL-00435	ENSORLG00000006714	SRC (2 of 2)