※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ORA-00251	ENSOANG00000005650	TGFBR2
2		EKS-ORA-00247	ENSOANG00000012302	BMPR2
3		EKS-ORA-00243	ENSOANG00000006133	ACVR1C
4		EKS-ORA-00242	ENSOANG00000006134	ACVR1
5		EKS-ORA-00246	ENSOANG00000012804	BMPR1B
6		EKS-ORA-00252	ENSOANG00000030744	LOC100681254
7		EKS-ORA-00241	ENSOANG00000014872	TGFBR1
8		EKS-ORA-00248	ENSOANG00000003970	ACVRL1
9		EKS-ORA-00250	ENSOANG00000011923	ACVR1B
10		EKS-ORA-00244	ENSOANG00000008907	BMPR1A
11		EKS-ORA-00249	ENSOANG00000008384	ACVR2A
12		EKS-ORA-00245	ENSOANG00000010530	TGFBR2