※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

  Reviewed (14)  or Unreviewed (2) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-MUM-00013	ENSMUSG00000019178	mCG_1870; Styxl1
2		EPS-MUM-00017	ENSMUSG00000026544	Ldp3; Dusp23
3		EPS-MUM-00009	ENSMUSG00000026564	Dusp27
4		EPS-MUM-00015	ENSMUSG00000030002	Dusp11; Pir1
5		EPS-MUM-00004	ENSMUSG00000039661	Dusp26; Skrp3
6		EPS-MUM-00012	ENSMUSG00000026659	Dusp12
7		EPS-MUM-00007	ENSMUSG00000003518	Dusp3
8		EPS-MUM-00008	ENSMUSG00000018648	Mkp6; Dusp14
9		EPS-MUM-00016	ENSMUSG00000063235	Ptpmt1
10		EPS-MUM-00006	ENSMUSG00000047205	Dusp18
11		EPS-MUM-00005	ENSMUSG00000025043	Dusp21
12		EPS-MUM-00010	ENSMUSG00000069255	Dusp22
13		EPS-MUM-00003	ENSMUSG00000021768	Mdsp; Dusp13
14		EPS-MUM-00002	ENSMUSG00000063821	Dupd1
15		EPS-MUM-00011	ENSMUSG00000042662	Dusp15
16		EPS-MUM-00014	ENSMUSG00000055493	Epm2a