※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.

  Reviewed (0)  or Unreviewed (11) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-CAJ-00374	ENSCJAG00000009293	LOC100392203; FGR
2		EKS-CAJ-00371	ENSCJAG00000021512	SRC
3		EKS-CAJ-00373	ENSCJAG00000020750	LOC100389637; HCK
4		EKS-CAJ-00376	ENSCJAG00000000957	LCK
5		EKS-CAJ-00377	ENSCJAG00000004076	BLK
6		EKS-CAJ-00370	ENSCJAG00000000099	YES1
7		EKS-CAJ-00375	ENSCJAG00000004595	FRK
8		EKS-CAJ-00369	ENSCJAG00000004878	FYN; LOC100391434
9		EKS-CAJ-00379	ENSCJAG00000010243	PTK6
10		EKS-CAJ-00378	ENSCJAG00000010253	SRMS
11		EKS-CAJ-00372	ENSCJAG00000016635	LYN