※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-MOD-00354	ENSMODG00000017905	FYN
2		EKS-MOD-00362	ENSMODG00000017852	FRK
3		EKS-MOD-00357	ENSMODG00000017464	LCK
4		EKS-MOD-00359	ENSMODG00000009142	LYN
5		EKS-MOD-00358	ENSMODG00000019471	HCK
6		EKS-MOD-00356	ENSMODG00000021477	LOC100011754
7		EKS-MOD-00361	ENSMODG00000020296
8		EKS-MOD-00355	ENSMODG00000000247	SRC
9		EKS-MOD-00364	ENSMODG00000016881	PTK6
10		EKS-MOD-00363	ENSMODG00000016887	SRMS
11		EKS-MOD-00360	ENSMODG00000011985	BLK