※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.

  Reviewed (11)  or Unreviewed (0) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-MUM-00403	ENSMUSG00000000409	Lsk-t; Lck
2		EKS-MUM-00400	ENSMUSG00000042228	Lyn
3		EKS-MUM-00401	ENSMUSG00000003283	Hck
4		EKS-MUM-00405	ENSMUSG00000019779	Bsk, Iyk; Frk
5		EKS-MUM-00397	ENSMUSG00000019843	Fyn
6		EKS-MUM-00406	ENSMUSG00000027579	Srm; Srms
7		EKS-MUM-00398	ENSMUSG00000027646	Src
8		EKS-MUM-00399	ENSMUSG00000014932	Yes1; Yes
9		EKS-MUM-00404	ENSMUSG00000014453	Blk
10		EKS-MUM-00407	ENSMUSG00000038751	Sik; Ptk6
11		EKS-MUM-00402	ENSMUSG00000028874	Fgr