※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.

  Reviewed (0)  or Unreviewed (10) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SAH-00336	ENSSHAG00000010594	FYN
2		EKS-SAH-00345	ENSSHAG00000018321	PTK6
3		EKS-SAH-00343	ENSSHAG00000018366	FRK
4		EKS-SAH-00344	ENSSHAG00000018268	SRMS
5		EKS-SAH-00341	ENSSHAG00000001546	FGR
6		EKS-SAH-00340	ENSSHAG00000008545	LCK
7		EKS-SAH-00337	ENSSHAG00000017529	SRC
8		EKS-SAH-00338	ENSSHAG00000011662	LYN
9		EKS-SAH-00342	ENSSHAG00000011673	BLK
10		EKS-SAH-00339	ENSSHAG00000011725	HCK