※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-NOL-00262	ENSNLEG00000004162	TGFBR2
2		EKS-NOL-00263	ENSNLEG00000007004	BMPR2
3		EKS-NOL-00258	ENSNLEG00000002425	BMPR1A
4		EKS-NOL-00257	ENSNLEG00000014109	BMPR1B
5		EKS-NOL-00255	ENSNLEG00000000817	ACVR1C
6		EKS-NOL-00254	ENSNLEG00000000837	ACVR1
7		EKS-NOL-00261	ENSNLEG00000005401	ACVR2B
8		EKS-NOL-00256	ENSNLEG00000017765	ACVR1B
9		EKS-NOL-00259	ENSNLEG00000017766	ACVRL1
10		EKS-NOL-00264	ENSNLEG00000017698	AMHR2
11		EKS-NOL-00253	ENSNLEG00000017038	TGFBR1
12		EKS-NOL-00260	ENSNLEG00000009051	ACVR2A